These lesions are present as symmetrical distributions on the extensor surfaces of the extremities. Pdf erythema multiforme is an acute or chronic inflammatory mucocutaneous manifestation of variable morphological expression. Erythema multiforme em is an interesting dermatologic disease which has oral manifestations. Erythema multiforme em is an acute mucocutaneous condition caused. In the oral cavity, the vesicleblister and erosive lesions can be caused by a considerable variety of disorders. The minor form is additionally subdivided into papular and vesiculobullous variants, and all three have been considered a continuum of the same process. The oral lesions are accompanied by rapidly rupturing vesicles and bullae leading to diffuse sloughing and ulceration of the whole surface of the skin and mucous membrane. Oral erythema multiforme em is considered as a third category of em other than em minor and major. Is erythema multiforme associated with bupropion use.
The diagnosis was con firmed as herpes simplex virusassociated erythema multiforme major. Both hsv 1 and hsv 2 trigger the erythema multiforme lesions. Eritema multiforme menor desencadeado por sulfametoxazol. A band of inflammation of the periodontium, appearing as a reddish gingival band about 2 to 3 mm in width.
Oral lesion appears along with skin lesion in 70 %. Number iv erythema multiforme farthing 2005 oral diseases. Oral surg oral med oral pathol oral radiol endod 1999. Erythema multiforme em is an acute disorder of the skin and mucosal membranes manifesting in the oral cavity 6070% of all patients as polymorphic erosive, ampullar, and bloodstained crusts. It is an uncommon disorder, with peak incidence in the second and third decades of life.
Herpes associated erythema multiformea diagnostic dilemma. The etiology is unclear, although an autoimmune mechanism is involved. Em minor, a mild allergic reaction, occurs most commonly. Erythema multiforme em has been divided into a minor simplex form and a major bullous form. If you continue browsing the site, you agree to the use of cookies on this website. The aim of this article is to report a case of oral manifestations of emm caused by sulfamethoxazoletrimethoprin, in addition to addressing the pathogenesis and treatment of this pathology. This means that the body is sensitive to something that causes the skin and mucous membranes to react. It is characterized by a skin eruption, with or without oral or other mucous membrane lesions.
It presents a diagnostic dilemma because the oral cavity has the ability to produce varied manifestations. Em is clinically characterized by a minor form and a major form. Prevalence of oral em varies from 35% to 65% among patients with skin lesions. Erythema multiforme major is the term used to describe em with mucosal involvement and may have associated. We report a case of recurrent herpesassociated erythema multiforme managed with prophylactic acyclovir. Journal of dental sciences management of antibiotic induced oral manifestation of erythema multiforme. Eryhema multiforme is an acute, selflimited condition characterized by the abrupt onset of symmetrical fixed red papules some of which evolve into target lesions. Erythema multiforme em is a rare, acute inflammatory disorder that affects skin, or mucous membranes, or both. Here you can read posts from all over the web from people who wrote about aids and erythema nodosum, and check the relations between aids and erythema nodosum. An 11yearold boy had lesions in the oral cavity and lips, which had been diagnosed as erythema multiforme minor. Management of erythema multiforme associated with recurrent.
Erythema multiforme em is an acute, selflimited, inflammatory cutaneous disorder caused by infection or drugs that is characterized by bulls eye lesions, blisters, and erythematous plaques on the skin fitzpatrick and bernhard 1987. Dermis erythema exsudativum multiforme, minor form. It has been reported that primary attacks of oral em is confined to the. Erythema multiforme em is a skin condition of unknown cause. Multiforme polymorphic first classified by bastuji garin et al to separate from sjs ten in 1922 described by hebra in 1866 as. Histologically, each shows varying degrees of dermal and epidermal inflammation and injury. The target lesion is characterized by concentric zones of colour changes with a central dusky or purple zone and an outer red. Erythema multiforme is usually a reaction of the skin and mucous membranes that occurs suddenly. We were unable to classify these patients as em major or sjs according to the criteria. Em usually affects apparently healthy young adults and the peak age at presentation is 2040 years although as many as 20% of cases are children.
Erythema multiforme is a disorder of the skin and mucosal membranes, manifesting as erythematous and vesicleblister lesions. Erythema multiforme is an acute mucocutaneous hypersensitivity reaction with a variety of etiologies. Erythema multiforme associated with the use of fluoxetine a case report in psychiatry online. Symptoms improved without blister formation and the patient was discharged the next day on a tapering dose of oral prednisone without further complications or symptom return. Erythema multiforme and fluoxetine priory journals. Patogenia del eritema gingival lineal by karina torres on. The reaction pattern appears as a result of allergic host response to antigenic challenge. Infections and drugs have been implicated in the etiopathogenesis. It appears as a symmetrical rash and may include the mucous membrane lesions.
Linear gingival erythema definition of linear gingival. Erythema multiforme is an acute mucocutaneous disorder, characterized by varying degrees of blistering and ulceration. Erythema multiforme em is an acute mucocutaneous hypersensitivity reaction characterised by a skin eruption, with or without oral or other. Erythema multiforme is a type of reactive mucocutaneous disorder. Erythema multiforme introduction and epidemiology erythema multiforme em is an acute, immunemediated condition, most commonly induced by herpes simplex virus hsv infection, or by the use of medications, such as phenytoin, sulfonamides, penicillins, and barbiturates. Introduction erythema multiforme em is an acute, immunemediated condition characterized by the appearance of distinctive, targetlike lesions on the skin. Patients present with oral and lip ulcerations typical of em but without any skin target lesions. Erythema multiforme an overview sciencedirect topics. These lesions are often accompanied by erosions or bullae involving the oral, genital, andor ocular mucosae picture 1af. Stevensjohnson syndrome at one time considered to be a separate disease mucocutaneousocular disease now recognized as simply a very severe bullous form of em with widespread involvement typically including the skin, oral cavity, eyes and genitalia.
1155 988 1139 1085 940 900 1094 1307 287 983 380 1136 704 186 1371 1423 194 1320 567 382 76 1414 847 1169 636 612 1028 1436